Analytical Laboratory: Toxicity Testing
Using toxicity testing data to test hypotheses about advanced-generation ECIGs and generate population-level predictions regarding potential regulatory action
Project 1’s (Project Director: Dr. Alan Shihadeh) specific aims are to use established aerosol research methods to examine how ECIG emissions are influenced by three potential regulatory actions: (1) limits on liquid nicotine concentration, (2) constraints on nicotine flux and (3) reduction in flavor availability. This work is informed by the Contextual Knowledge Core (Core Director: Dr. Pebbles Fagan).
Project 1 will provide new data regarding the role of nicotine concentration, flux and liquid availability on ECIG toxicity, while informing predictions regarding the consequences of potential regulatory action. These predictions will then be examined at the population level within Project 4’s prospective cohort survey (Project Director: Dr. Joanna Cohen).
Thus, Project 1 is part of an integrative theme of impact analysis and draws on the team’s aerosol research expertise to provide FDA tools that can be used to guide regulation development so that, by the time a regulation goes into effect, methods predictive of population-level phenomena have tested it, refined it and generated data that show its health-promoting effects are maximized and unintended consequences are minimized.