Effects of Electronic Cigarette Settings and Liquid Concentrations 

in Cigarette Smokers and Electronic Cigarette Users

Purpose: The purpose of this research study is to find out how different types of electronic cigarettes settings, combined with e-liquids of differing nicotine concentrations, affect blood nicotine levels, use behavior (how you puff), and how you feel.

Study Details:  If you meet the eligibility criteria, we will ask you to participate in 6 sessions, which last approximately 4 hours. Before each visit, we will ask you to abstain from all tobacco products for at least 12 hours. At the beginning of each session a nurse will insert an IV catheter into your arm that will stay there for the entire session. This catheter will be used to draw blood periodically (less than 1 tablespoon per sample, 4 samples). During each session, we will also monitor your heart rate and blood pressure and ask you to respond to several questionnaires to measure how you feel. In each session, you will receive an e-cigarette filled with e-liquid. During the session we will ask you to use the electronic cigarette we provide at two separate times. 

Confidentiality: We will not tell anyone the answers you give us; however, information from the study and the consent form signed by you may be looked at or copied for research or legal purposes by the sponsor of the research, or by Virginia Commonwealth University.

Payment: You will be paid for the time that you are not using tobacco prior to session and for your time in the laboratory: you will receive $50 after the first session, $75 after the second, $100 after the third and fourth, $150 after the fifth sessions, and $175 after the sixth session. In all, you can earn $650 for completing this study. All payments will be in cash.

Assessment of Two New Electronic Cigarettes in Cigarette Smokers

Purpose: The purpose of this study is to better understand how different types of electronic cigarettes affect blood nicotine levels and how you feel.

Study Details: If you meet the eligibility criteria, we will ask you to participate in three, approximately 4-hour sessions. Before each session, we will ask you to abstain from all tobacco and nicotine containing products for at least 12 hours. We will also ask you to abstain from caffeinated beverages for 1 hour before each session. At the beginning of the session, a nurse will insert an IV catheter into your arm that will stay there for the entire session. This catheter will be used to draw blood periodically (less than 1 tablespoon per sample). During each session, we will also monitor your heart rate and blood pressure and ask you to respond to several questionnaires to measure how you feel.

In each session, you will receive either an e-cigarette or your own brand cigarette. During the session we will ask you to use the product we provide at two separate times.

Confidentiality: We will not tell anyone the answers you give us; however, information from the study and the consent form signed by you may be looked at or copied for research or legal purposes by the sponsor of the research, or by Virginia Commonwealth University.

Payment: You will receive $75 after the first session, $100 after the second, and $125 after the third session. In all, you can earn $300 for completing this study.

Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers  

Purpose: This study aims to understand the effects of device power and nicotine concentration on the likelihood that someone would use or abuse e-cigarettes.

Study Details: If you meet eligibility criteria, we will ask you to participate in five, approximately 4-hour sessions. Before each session, we will ask you to abstain from all tobacco and nicotine containing products for at least 12 hours. We will also ask you to abstain from caffeinated beverages for 1 hour before each session.

In each session you will have an opportunity to complete two behavioral tasks focused on either an e-cigarette or your own brand e-cigarette/cigarette. One task will ask you to work to earn puffs of the session product. The other task will ask you to choose between puffs of the session product and various amount of compensation.

Confidentiality: We will not tell anyone the answers you give us; however, information from the study and the consent form signed by you may be looked at or copied for research or legal purposes by the sponsor of the research, or by Virginia Commonwealth University.

Payment: If you are eligible and choose to participate, you will be asked to complete a behavioral task where you can earn up to $50 at the in-person screening. You will receive $75 after the first session, $100 after the second, third and fourth sessions, and $125 after the fifth session. In all, you can earn $500 for completing this study.